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    Hyperpigmentation Removal Products Improve With the Addition of Snail Secretions

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    Unusual build-up of melanin in skin shows up as tanning, uneven skin tone, melasma (localized post-partum darkening of the skin) or age spots. Undesirable coloring make individuals uneasy, and decrease their self-confidence and sensations of self-worth. Here we report the depigmentation effectiveness of Bioskinrejuvenation, a cosmetic cream powered by snail secretions with powerful anti-oxidants.

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    Andes Natural Skin Care, LLC has added to its Biocutis ® line of natural skin care products Bioskinrejuvenation with two effective depigmentation agents: Rumex Extract and a nonapeptide derived from the melanocyte-stimulating-hormone, plus snail secretions with powerful antioxidants. The later makes hyperpigmentation removal with this product much more effective.

    Skin color is mostly attributable to the quantity, quality, and distribution of melanin. The effects of surface area blemishes and unusual melanin accumulation on the unevenness of skin tone have been thoroughly explained by the dermatology field.

    Melanin accumulation in the skin can be due to numerous causes such as hormonal imbalance or sun exposure, and could be either transient or long-term if not irreversible, as observed in conditions such as tanning, uneven skin tone, melasma (“the mask of pregnancy”), post inflammatory hyperpigmentation after acne resolves, or age spots.

    Skin hyperpigmentation, and the reactions that precipitates it, have been associated with free radicals by the fact that free radical scavengers or anti-oxidants can slow hyper pigmentation. Snail secretions from the species Helix Aspersa or Cryptomphalus Aspersa are powerful antioxidants utilized by this species to shield from solar radiation and during arousal from estivation.

    Estivation is a state of animal dormancy, similar to hibernation, characterized by inactivity, a lowered metabolic rate, and lack of oxygen inside the shell where they enter in response to high temperatures and arid conditions. When the snail arouses out of the shell, it goes into an environment loaded with “dangerous” oxygen and secretes large quantities of its protective antioxidants.

    The snail secretions were extensively screened by scientists from some of the most prominent dermatology services in the world, such as the Hospital Universitario de la Princesa, Universidad Autonoma, Madrid, Spain and the Memorial Sloan-Kettering Cancer Center in New York. They concluded that the secretions are moisturizing, have skin regeneration, and effective antioxidant properties when placed on human skin. (1) (2)

    UVB induces melanin production in skin type III skin, which is observed as a tan a couple of days after exposure. We checked the capability of skin depigmenting products to affect the rate of melanin loss after tanning, and to assess the effect of the antioxidant snail secretions on this process.

    When a product with nonapetide 1 and Rumex extracts with and without snail secretions was checked in human volunteers using an in vivo assay, Bioskinrejuvenation with the snail secretions yielded an increase in the rate of fading hyperpigmentation compared to the formulation with only Rumex Extracts and the nonapeptide 1; and likewise at a faster rate than a product developed with prescription 4 % hydroquinone utilized as positive control.

    These results show that skin depigmentation can be achieved using potent natural antioxidants to reach performance levels similar to the ones acquired with standard prescribed drugs that contain hydroquinone.

    These are good news because hydroquinone contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including serious, potentially life-threatening allergic responses marked by swelling, hives, lowered blood pressure, and dilated blood vessels, and life-threatening or less severe asthmatic episodes in certain susceptible people.

    Hydroquinone may also produce a gradual blue-black darkening of the skin. If this condition occurs, treatment must be discontinued. The majority of patients developing this condition are Black, but it may also occur in Caucasians and Hispanics.

    Hyperpigmentation can affect all skin types but people of black skin gets affected the most.

    There are a few subtle differences between caucasian skin and skin of color, so it helps to bear this in mind when treating hyperpigmentation on black skin. The thickness of the epidermis or outer layer of the skin on white and black skin is the same; the epidermis in black skin however, does have more cell layers, which makes it more difficult to remove excess melanin deposits.

    The biggest difference between caucasian skin and skin of color is in how the skin reacts to acne. Darker skin will react to inflammation with an excess deposit of melanin. The condition is known as Post Inflammatory Hyperpigmentation (PIH).

    Andes Natural offers Bioskinforte, a strong natural acne treatment cream designed to tackle the root causes of acne. Bioskinforte, available at amazon.com and at biocutis.com, tackles acne and eliminates redness and post inflammatory hyperpigmentation. If that does not work then Bioskinrejuvenation gets rid of sticky hyperpigmentation.

    Bioskinforte and other Biocutis natural skin care products for dry skin, dermatitis, rosacea, eczema, keratosis, acne scars, stretch marks, cellulite, ingrown hairs, wrinkles, and more are available at the company's website biocutis.com and at amazon.com. Bioskinrejuvenation for hyperpigmentation removal is only available at biocutis.com now but will be at amazon.com soon.

    References: 1) Molecular basis for the regenerative properties of a secretion of the mollusk Cryptomphalus aspersa. Skin Pharmacology and Physiology, 2008. 2) A secretion of the mollusc Cryptomphalus aspersa promotes proliferation, migration and survival of keratinocytes and dermal fibroblasts in vitro. International Journal of Cosmetic Science, 2012.

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  • Quotes
    Helix aspersa snails have skin that is very similar to human skin and cope with the challenges that result from thriving exposed nude to the environment by secreting a serum made by the cells of their innate immune system, which is more evolved than our innate immune system. The serum is a complex compound of molecules, so complex that it cannot be replicated even in the most sophisticated laboratory; and sets a benchmark for ingredients designed to repair and regenerate damaged skin.
    - Mario Reyes, Chemist, Member of The New York Academy Of Sciences.
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    Melasma HyperpigmentationHelix Aspersa Snails of Different Colors
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    Marie Claude Niel



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